A simple method based on the dynamic reaction cell (DRC) technology to eliminate the spectral interference in the simultaneous determination of trace cadmium and silver in soil samples by ICP-MS was established. Under the optimized O2 flow rate (2.7 mL min-1) and the DRC rejection parameter RPq (0.8 for Ag, 0.7 for Cd), the interference caused by Zr, Nb, and Mo (such as 95Mo16O+, 94Mo16OH+, 94Zr16OH+ on 111Cd+ and 93Nb16O+, 92Zr16OH+ on 109Ag+) could be effectively eliminated, and the background signal was reduced up to 100-fold at m/z 109 and 111. The limit of quantitation (LOQ, 10σ) for 109Ag+ and 111Cd+ was 0.1 and 0.2 ng g-1, respectively. The proposed method was applied to the direct determination of Ag and Cd in soil standard reference materials, and the results were in good agreement with the certified values.