The strontium (Sr) isotopic composition of the atmospheric particulate samples was measured using single-quadrupole inductively coupled plasma mass spectrometry. After the multivariate optimization of the main operating conditions (sample uptake rate, spray chamber temperature, and quadrupole voltages), the 87Sr/86Sr isotopic ratio was measured with an internal precision of ~0.1% (%RSD, n=12) at the Sr concentration of 2?10 μg L?1 and ~0.2% at 0.5?2 μg L?1. The isobaric interferences were mathematically fixed, whereas the instrumental mass bias was efficiently corrected by a combination of internal corrections based on the measurement of the 88Sr/86Sr ratio and bracketing external calibration. Finally, an optimized Sr isolation procedure produced a low procedural blank (0.05±0.01 μg L?1) and good recovery (78±7%) at a low Sr concentration (0.5?2 μg L?1). The applicability of the developed method was demonstrated by the analysis of a time series of PM10 samples collected from the Antarctic Plateau, which are characterized by a low Sr concentration and limited sample mass. The results were in excellent agreement with those published in the literature.