Fluorine determination techniques using inductively coupled plasma-tandem mass spectrometry (ICP-MS/MS), which depend on BaF? detection, are severely constrained in foods with high sulfate content because of the precipitation of barium sulfate. For this purpose, a chloride-enhanced SrF? method was developed using ICP-MS/MS and ammonia as the reaction gas. The signal response of SrF? was increased by up to ~3-fold relative to that in water as the solvent under controlled standard conditions by adding chloride as 4% HCl, which was mechanistically related to the formation of the SrCl+ intermediate. The water-related interferences were lowered by 80% using the Peltier cooling system to keep the spray chamber at ?2 °C. The method showed a linear range of 1?20 mg L?1, an analytical sensitivity of 2.6×103 CPS/mg L?1, and a method detection limit of 4.5×10?3 mg L?1 for fluorine. It demonstrated improved resistance to elevated sulfate concentrations, overcoming one of its main limitations of BaF?-based methods. Analysis of quality control samples and certified reference materials for validation demonstrated good agreement with certified values, while spike recoveries in real food samples ranged from 94.2% to 99.8%.